【Abstract】 ObjectiveToinquireintodiagnosis,differentialdiagnosisandtreatmentofvirilizingandfeminizingadrenalsyndromeespecialydifferentialdiagnosisbetweenbenighandmalignantofsexhormoneproducingadrenalneoplasmaandtreatmentprinciplesofcongenitaladrenalhyperplasia（CAH）. Method EightcasesofCAHandfivecasesofsexhormoneproducingadrenalneoplasmawerepresentedduring1986～1996.Theformerincluded3rarecasesof17αhydroxylasedeficiencyandothers.Thelatterincluded3casesoffeminizingadrenaltumorsand2casesofvirilizingadrenaltumors. Result Weightanddiameteroftumor,DHEA,17-ksandsexhormonelevels,appearanceofCTimaging,infiltrationandmetastasis,werecloselyrelatedtodifferentiationofbenighandmalignenttumors. Conclusion Somestandardsarenotabsolutebecauseoflimitedpractice,follow-upisveryimportant.Adrenalvirilizingandfeminizingneoplasmsweresurgicallyresectedbydifferentincision.Modifiedsubcostalincisionisrecommendedasabestchoiceforhugeadrenalmass.CorticoadrenalhormonetreatmentofCAHshouldselectdifferentkindofcorticoadrenalmedicinefordifferentkindofCAH.Treatmentofsexhormonesisnotsuitableforchildrensufferedfrom17hydroxylasedificincyuntilprepuberty.
